ImageXpress Micro 4 High-Content Imaging System

ImageXpress Micro 4 High-Content Imaging System

Configurable, high-throughput widefield imaging solution for an incredible
range of assays

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Widefield imaging for basic research through to high-content screening

The ImageXpress® Micro 4 High-Content Imaging System is a high-throughput, widefield imager that can acquire images of whole organisms and cellular or intracellular events. It features proprietary fast frame rate technology, allowing for the capture of fast biological processes such as calcium oscillations in cardiomyocytes. It is highly configurable and adaptable to changing research needs. Available options include confocal, brightfield, phase contrast, liquid handing, and environmental control.

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Support many cellular assays

Image an incredible range of assays with various user-changeable filter cubes, 1-100x objectives, environmental control, fluidics option, and many sample formats including atypical plates for 3D assays.

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Analyze images of more applications

A selection of feature-rich turnkey application modules is available with MetaXpress® software. For the development of novel assays, we offer an optional custom analysis module.

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Tailor the system to meet your needs

The imager is a highly flexible solution, you can add or change many of the components as your research priorities change. Examples include enhance light engines and automation.

ImageXpress Micro 4 Imaging System


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Multiple imaging modes

The system offers fluorescence, widefield, colorimetric, phase contrast, and brightfield label-free imaging.

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Upgradeable to confocal

The system can be upgraded to include the proprietary AgileOptix™ technology for accurate 3D volumetric analyses.

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Wide dynamic range

Low and high intensity signal quantification in a single image with >3 log dynamic range intensity detection.

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High speed image acquisition

Using 4x magnification with a 1536-well plate, 225K wells per day can be acquired. Greater than a million wells per week can be imaged.

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Optional environmental control

Temperature, humidity, and CO2 control for multi-day live-cell imaging or fast kinetic studies are available.

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Large magnification range

Air and oil immersion objectives ranging from 1x to 100x are available for installation into the 4-position objective changer.

Introducing the MetaXpress 3D Analysis Toolkit

MetaXpress high-content image aquisition and analysis software

  • Meet high throughput requirements with a scalable, streamlined workflow
  • Adapt your analysis tools to tackle your toughest problems, including 3D analysis
  • Schedule automatic data transfer between third-party hardware sources and secure database
  • Set up hundreds of routinely used HCS assays using MetaXpress software modules

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Customer Breakthrough

Forcyte Biotechnologies uses ImageXpress Micro 4 to execute mechano-medicine discovery screens


Forcyte Biotechnologies uses the ImageXpress Micro 4 system to help execute mechano-medicine discovery screens

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How can we help advance your next big discovery?

Our highly-qualified teams are on the frontlines with our customers, conducting remote or on-site product demonstrations, webinars, and more to help you solve your tough research challenges. How can we help you today?

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Expand your research using flexible imaging solutions

Molecular Devices provides flexible options for the ImageXpress Micro 4 High-Content Imaging System to meet your research needs and to easily capture images from different sample formats, including hanging drops and in round or flat bottom plates, for monitoring cell health kinetics under environmental control, and more.

urnkey, high-throughput long term kinetics


Environmental control maintains temperature and humidity levels while minimizing evaporation for multi-day, live cell, time-lapse imaging.

Phrase Contrast


Our transmitted light tower enables acquisition of high contrast images for unstained cells which can be easily viewed or separated from background.

Robotic Automation


Integrated fluidics automates assay workflows which require compound addition, well washing, and media exchange.

Implement a solution that works for you

Molecular Devices can successfully tailor the ImageXpress Micro 4 High-Content Imaging System to include customized software and hardware including the features described herein, as well as integration of other lab components such as incubators, liquid handlers, and robotics for a fully automated workcell. With over 30 years of experience in the life science industry, you can count on us to deliver quality products and provide worldwide support.

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Applications of ImageXpress Micro 4 High-Content Imaging System

Specifications & Options of ImageXpress Micro 4 High-Content Imaging System

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Resources of ImageXpress Micro 4 High-Content Imaging System

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