Disease Modeling

Understanding the biology of human diseases is crucial to find effective treatment, and cell lines derived from cancer tissues help develop better anti-cancer drugs. However, now there is a pressing need to increase complexity and relevance of cell-based models to more accurately predict the effects of new drug candidates. Genetically engineered human or animal cells that carry disease mutation display all or some of the pathological processes observed in actual human disease. Designing 3D models that mimic tissues and cell interactions allows researchers to better predict drug effects. 3D cell models, including spheroids, organoids, and organ-on-a-chip, can be built from established cell lines derived from iPSC cells or patient derived cells. Cells can be derived from patient tissue representing rare type of cancer, or genetically modified to introduce or repair disease-related genes.