Whole Organisms

Model systems such as Drosophila, C. elegans, and zebrafish offer relevance to human biology, with the added advantage of genetic and whole-organism phenotypic screening. Zebrafish screening has gained favor as an alternative to mammalian screening due to reduced cost and space requirements, short generation times, and ease of genetic manipulation. Our zebrafish studies use the ImageXpress Micro System and MetaXpress software to set up and run automated imaging screens to monitor inhibition of angiogenesis, quantitate gene knockdown, and measure ototoxicity and neurotoxicity.