Scientific poster: Neurotoxicity evaluation using iPSC
Multiplexed automated assays for neurotoxicity evaluation using induced pluripotent stem cell-derived neural 3D cell models
Cell-based phenotypic assays have become an increasingly attractive alternative to traditional in vitro and in vivo testing in pharmaceutical drug development and toxicological safety assessment. The effectiveness of automated imaging assays combined with the organotypic nature of human induced pluripotent stem cell (iPSC)-derived cells opens new opportunities to employ physiologically relevant in vitro model systems to improve screening for new drugs or potential chemical toxicities. In our studies, we used human iPSC-derived neural cultures to test functional and morphological end points for toxicity evaluation in a multi-parametric assay format.