Dated: Apr 20, 2021
Publication Name: ScienceDirect
Citations : Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection
Considerable concerns relating to the duration of protective immunity against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) exist, with evidence of antibody titers declining rapidly after infection and reports of reinfection. Here, we monitor the antibody responses against SARS-CoV-2 receptor-binding domain (RBD) for up to 6 months after infection. While antibody titers are maintained, ∼13% of the cohort’s neutralizing responses return to background.
Contributors: Arunasingam Abayasingam, Harikrishnan Balachandran, David Agapiou, Mohamed Hammoud, Chaturaka Rodrigo, Elizabeth Keoshkerian, Hui Li, Nicholas A. Brasher, Daniel Christ, Romain Rouet, Deborah Burnet, Branka Grubor-Bauk, William Rawlinson, StuartTurville, Anupriya Aggarwal, Alberto Ospina Stella, Christina Fichter, Fabienne Brilot…Rowena A. Bull