Optimization of NaV1.5 channel assay

Voltage-gated ion channels are present in the excitable cell membranes of heart, skeletal muscle, brain and nerve cells. Blocking or modulating such channels can have a therapeutic effect, or may interfere with normal cell function. As a result, compounds that affect voltage-gated ion channels are important targets in drug discovery.

The FLIPR® Membrane Potential Assay Kits deliver homogenous fluorescence-based formulations for observation of real-time membrane potential changes associated with ion channel activation and ion transporter proteins.

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Optimization of NaV1.5 channel assay with FLIPR Membrane Potential Assay Kit