Ligand gated ion channels (LGICs)

Ligand gated ion channels (LGICs) are a large family of membrane embedded proteins that enable the passage of ions across membranes, in response to the binding of ligands such as neurotransmitters. LGICs represent a class of highly attractive drug targets because of the pivotal role they play in many physiological functions, and their association with multiple human diseases.

• Validation of TRPV1 and ASIC1 ligand-gated ion channels using automated patch clamp and FLIPR with novel Ca 2+ detection dye
• Assay Development of Ligand- and Voltage-Gated Ion Channels on Automated Patch Clamp Systems
• FLIPR Calcium Assay Kits
• FLIPR Potassium Assay Kit