Dated: Apr 06, 2023
Publication Name: Biotechnology and Genetic Engineering Reviews
Citations : Cinobufacini suppresses malignant behaviors of endometrial cancer by regulating NF-κB pathway
inobufagin has inhibitory effects on various tumors, but there are few studies on gynecological tumors. This study explored the function and molecular mechanism of cinobufagin in endometrial cancer (EC). Different concentrations of cinobufagin treated EC cells (Ishikawa and HEC-1). Clone formation, methyl thiazolyl tetrazolium (MTT), flow cytometry, and transwell assays were used to detect malignant behaviors. A Western blot assay was performed to detect protein expression. Cinobufacini was sensitive to the inhibition of EC cell proliferation in a time- and concentration-dependent manner.
Contributors: Mengyi Sun, Xiaodao Han, Xiaoyun Liu and Yintao Xu