Dated: Jun 14, 2023
Publication Name: Biomaterials
Citations : Blue light promotes vitamin C-mediated ferroptosis of melanoma through specifically upregulating transporter SVCT2 and generating Fe2+
Vitamin C (VC)-based cancer therapy is a promising therapeutic approach for a variety of cancers due to its profound effects on redox reactions and metabolic pathways. However, high administration dosage of VC for necessary therapeutic efficacy for cancers increases the risk of overt side effects and limits its clinical use. Here, we show cutaneous blue light irradiation can specifically upregulate the sodium-dependent vitamin C transporter 2 (SVCT2) of the tumor and increase effectively the VC concentration at the tumor sites by an overall low dosage administration.
Contributors: Rong Yang, Fangqing Deng, Yingchun Yang, Qing Tian, Shuaiqi Huangfu, Luqiu Yang, Jing Hou, Guanghao Yang, Wei Pang, Jueru Lu, Hui Liu, Yao Chen, Jie Gao, Lianbing Zhang